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Pharmaceutical Baclofen For Muscle Relaxant Agent CAS 1134-47-0

Pharmaceutical Baclofen For Muscle Relaxant Agent CAS 1134-47-0

Brand Name : JNJG
Certification : ISO 9001, USP, BP
Place of Origin : China
MOQ : 10g
Price : usd(1-10)/g
Payment Terms : Western Union, MoneyGram, T/T, Bank Transfer, Bitcoin
Supply Ability : 1000kg/month
Delivery Time : within 24 hours after your payment
Packaging Details : Discreet packing ways as your requirement, 100% go through
CAS : 1134-47-0
MF : C10H12ClNO2
MW : 213.66
EINECS : 214-486-9
Appearance : Off-White Solid
Usage : Muscle relaxant (skeletal).
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Active Pharmaceutical Baclofen For Muscle Relaxant Agent CAS 1134-47-0


Quick Detail:

Product Name

Baclofen


Alias

baclon;beta-(4-chlorophenyl)gaba;


CAS

1134-47-0


MF

C10H12ClNO2


MW

213.66


EINECS

214-486-9


Purity

99%


Appearance

Off-White Solid


Melting Point

208-210°C


Density

1.2069


Standard

Pharma Grade


Usage

Muscle relaxant (skeletal)


Storage

Store in cool and dry area and keep away from direct sunlight



Description:


Baclofen is a γ-aminobutyric acid derivative. It is an antispasmodics class drugs acting on the central nervous system, the brain and spinal cord as a skeletal muscle relaxants and sedatives. It take antispasmodic effect by stimulating receptors to inhibit the release of excitatory amino acids such as glutamic acid, aspartic acid and thereby inhibiting the transfer of single and multi-synaptic reflex in central nervous system, brain and spinal cord.


Clinically it has already been used as racemic agent for treating Muscle spasticity since mid-1960s.Recent studies have also found that this product can significantly reduce the symptoms of gastroesophageal reflux and alleviating related symptoms. It can also alleviate the dystonia of children and treat the urination dysfunction caused by central spinal cord injury. In addition, the intrathecal injection therapy of the product in clinical application can further improve the clinical efficacy, and make it possible to adjust drugs dosage which stabilizes the treatment effect


Specification:

Product Name

Baclofen


CAS No.1134-47-0Outer Packing

1kg


Production date2016.9.25Shelf life

2018.9.24


Standard

EP


Items of analysis

Specification


Results
AppearanceWhite or almost white powder

White powder


IdentificationUV or IR or TLC

Positive



Appearance of solution


≤Reference Suspension II ≤BY5Conforms
Water Content≤1.0%

0.03%


Purity98.0~101.0%

99.25%


Impurity A≤1.0%

Negative


Total impurities≤2.0%

0.01%


Conclusion

Qualified



Application:


(1) Baclofen (brand names Kemstro, Lioresal, Liofen, Gablofen, Lyflex, Beklo and Baclosan) is a derivative of gamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism. It is also used by compounding pharmacies in topical pain creams as a muscle relaxant.

(2) It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups.

(3)A beneficial property of baclofen is that tolerance does not seem to occur to a significant degree - baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use. Newer studies, however, indicate that tolerance may develop in some patients receiving intrathecal baclofen treatment.

(4)Medical uses: Baclofen is primarily used for the treatment of spastic movement disorders, especially in instances of spinal cord injury, cerebral palsy, and multiple sclerosis. Its use in people with stroke or Parkinson's disease is not recommende. 4. Mechanism of action: Baclofen produces its effects by activating the GABAB receptor, similar to the drug which also activates this receptor and shares some of its effects. However, baclofen does not have significant affinity for the receptor, and has no known abuse potential. The modulation of the GABAB receptor is what produces baclofen's range of therapeutic properties.

(5)Baclofen can be used as Specific GABA-B receptor agonist. Muscle relaxant (skeletal). It is primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism. In addition, research has shown baclofen to be effective in the treatment of alcohol dependence and withdrawal, by inhibiting both withdrawal symptoms and cravings.


Usage:


1. The product is a relaxant and antispasmodic agent acting on the skeletal muscle of spinal cord. Suitable for treating multiple-sclerosis bones spasms, spinal infection, degenerated muscle spasms; spinal cord trauma, and neoplastic muscle spasms.


2. It is currently the most effective muscle relaxants with least side effects.



Advantage:


1. We are a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.


2. Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 3000t each month.


3. Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany,Russia, Australia, New Zealand.


4. Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.


5. High quality, good price, fast and safety delivery. Shipment by DHL, TNT, FEDEX, HKEMS, UPS, etc.



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