Active Pharmaceutical Baclofen For Muscle Relaxant Agent CAS
Muscle relaxant (skeletal)
Store in cool and dry area and keep away from direct sunlight
Baclofen is a γ-aminobutyric acid derivative. It is an
antispasmodics class drugs acting on the central nervous system,
the brain and spinal cord as a skeletal muscle relaxants and
sedatives. It take antispasmodic effect by stimulating receptors to
inhibit the release of excitatory amino acids such as glutamic
acid, aspartic acid and thereby inhibiting the transfer of single
and multi-synaptic reflex in central nervous system, brain and
Clinically it has already been used as racemic agent for treating
Muscle spasticity since mid-1960s.Recent studies have also found
that this product can significantly reduce the symptoms of
gastroesophageal reflux and alleviating related symptoms. It can
also alleviate the dystonia of children and treat the urination
dysfunction caused by central spinal cord injury. In addition, the
intrathecal injection therapy of the product in clinical
application can further improve the clinical efficacy, and make it
possible to adjust drugs dosage which stabilizes the treatment
|CAS No.||1134-47-0||Outer Packing|
|Production date||2016.9.25||Shelf life|
|Items of analysis|
|Appearance||White or almost white powder|
|Identification||UV or IR or TLC|
Appearance of solution
|≤Reference Suspension II ≤BY5||Conforms|
(1) Baclofen (brand names Kemstro, Lioresal, Liofen, Gablofen,
Lyflex, Beklo and Baclosan) is a derivative of gamma-aminobutyric
acid (GABA). It is primarily used to treat spasticity and is in the
early research stages for use for the treatment of alcoholism. It
is also used by compounding pharmacies in topical pain creams as a
(2) It is an agonist for the GABAB receptors. Its beneficial
effects in spasticity result from actions at spinal and supraspinal
sites. Baclofen can also be used to treat hiccups.
(3)A beneficial property of baclofen is that tolerance does not
seem to occur to a significant degree - baclofen retains its
therapeutic anti-spasmodic effects even after many years of
continued use. Newer studies, however, indicate that tolerance may
develop in some patients receiving intrathecal baclofen treatment.
(4)Medical uses: Baclofen is primarily used for the treatment of
spastic movement disorders, especially in instances of spinal cord
injury, cerebral palsy, and multiple sclerosis. Its use in people
with stroke or Parkinson's disease is not recommende. 4. Mechanism
of action: Baclofen produces its effects by activating the GABAB
receptor, similar to the drug which also activates this receptor
and shares some of its effects. However, baclofen does not have
significant affinity for the receptor, and has no known abuse
potential. The modulation of the GABAB receptor is what produces
baclofen's range of therapeutic properties.
(5)Baclofen can be used as Specific GABA-B receptor agonist. Muscle
relaxant (skeletal). It is primarily used to treat spasticity and
is in the early research stages for use for the treatment of
alcoholism. In addition, research has shown baclofen to be
effective in the treatment of alcohol dependence and withdrawal, by
inhibiting both withdrawal symptoms and cravings.
1. The product is a relaxant and antispasmodic agent acting on the
skeletal muscle of spinal cord. Suitable for treating
multiple-sclerosis bones spasms, spinal infection, degenerated
muscle spasms; spinal cord trauma, and neoplastic muscle spasms.
2. It is currently the most effective muscle relaxants with least
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